New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
Christophe Le Clainche
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com :
www.nature.com/articles/s41...
aqv-days-2026.sciencesconf.org
Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica...
Not enough space in the first post to highlight the major contribution of Stéphane Roméro and Arthur Courtois from Alexis Gautreau’s lab @polytechniqueparis.bsky.social with the cell studies.
Thrilled to have contributed to this chem–bio collaboration
@polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light
JACS: doi.org/10.1021/jacs...
Thrilled to have contributed to this chem–bio collaboration
@polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light
JACS: doi.org/10.1021/jacs...
Christophe Le Clainche
I2BC is recruiting group leaders in several disciplines.
Don’t miss the chance to launch your team at Paris-Saclay.
Information : www.i2bc.paris-saclay.fr/wp-content/u...
Applications and enquiries : [email protected]
Deadline: April 22, 2026
I2BC is recruiting group leaders in several disciplines.
Don’t miss the chance to launch your team at Paris-Saclay.
Information : www.i2bc.paris-saclay.fr/wp-content/u...
Applications and enquiries : [email protected]
Deadline: April 22, 2026
Christophe Le Clainche
Christophe Le Clainche
Alushin Lab
Christophe Le Clainche
Christophe Le Clainche
Very excited to be sharing our new paper, just out in Nature Cell Biology!
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
Biophysical Paris
✍️The @bladoux.bsky.social / @rmmege.bsky.social Lab contributed to a new publication
📖 @science.org Advances
📃 Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization
🔗 www.science.org/doi/10.1126/...
