La Trobe University and WEHI, 5 human donors plus aged mice, found dying infected cells package live SARS-CoV-2 into apoptotic bodies.
Macrophages swallow them, triggering inflammasome and NF-κB inflammation.
www.nature.com/articles/s41...
This study reveals a novel, druggable route for SARS-CoV-2 infection and inflammatory responses in macrophages, thus expanding our understanding of COVID-19 pathogenesis and demonstrating a therapeuti...
