We like to look at bacteria do the things they do. Université de Montréal.
Yves Brun lab
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ANNOUNCEMENT! Programme now LIVE on our website for the #ProkaryoticCellBio conference! Check it out here, a reminder that the registration deadline is 13 April!➡️https://bit.ly/4rEH9KP
Our paper on the in situ structure of the Tad pili machine is now published in mBio journals.asm.org/eprint/D9AT2... #microsky
Our work with the Brun lab on the in situ architecture of the Caulobacter crescentus Tad pilus machine is published in mBio. Amazing collaborative effort led by James Iarocci @jamesiarocci.bsky.social
🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process.
www.biorxiv.org/content/10.6...
A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere www.biorxiv.org/content/10.1...
All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?
Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.
www.nature.com/articles/s41...
(1 out of 3)
New in JB: Mike Cashel is known internationally for his work on "magic spot", or (p)ppGpp, that serves as a key regulator of bacteria physiology. Hinman & Gottesman remember Dr. Cashel.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol
Video
Yves Brun lab
Shuaiqi Guo
Fusion Conferences
Aritz Roa-Eguiara
George O'Toole (he/him/his)
BejaLab
Luiz Pedro Carvalho, PhD
Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...
Investigating the Tad pilus nanomachine in a genetically tractable, non-pathogenic organism like Caulobacter crescentus provides a powerful model for elucidating the architecture and functional dynamics of this widespread system. Insights gained from studying the Tad machinery can improve our understanding of related Tad pilus systems in pathogenic bacteria such as Aggregatibacter actinomycetemcomitans, where Tad pili are a key determinant of biofilm formation and chronic infection. Additionally, the remarkable functional diversity of Tad systems, ranging from surface sensing in C. crescentus to bacterial predation in Myxococcus xanthus, highlights their broad biological relevance. By revealing the in situ architecture of the Tad pilus biosynthetic machinery, this study advances our understanding of a major class of bacterial nanomachines and may thus provide structural insights that could inform the development of new therapeutic strategies targeting pilus-mediated virulence.
Our paper on the in situ structure of the Tad pili machine is now published in mBio journals.asm.org/eprint/D9AT2... #microsky
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
Investigating the Tad pilus nanomachine in a genetically tractable, non-pathogenic organism like Caulobacter crescentus provides a powerful model for elucidating the architecture and functional dynamics of this widespread system. Insights gained from studying the Tad machinery can improve our understanding of related Tad pilus systems in pathogenic bacteria such as Aggregatibacter actinomycetemcomitans, where Tad pili are a key determinant of biofilm formation and chronic infection. Additionally, the remarkable functional diversity of Tad systems, ranging from surface sensing in C. crescentus to bacterial predation in Myxococcus xanthus, highlights their broad biological relevance. By revealing the in situ architecture of the Tad pilus biosynthetic machinery, this study advances our understanding of a major class of bacterial nanomachines and may thus provide structural insights that could inform the development of new therapeutic strategies targeting pilus-mediated virulence.
