Understanding where genomics models work and fail will be critical to their successful deployment. Meta models can tell us this, and give some insight into failure modes.
3/3 for @muntakimrafi.bsky.social this week. CSHL AIxBIO to boot (sorry to miss!) What a week!
Gigabase-scale deletion scanning of the human genome https://www.biorxiv.org/content/10.64898/2026.05.29.728882v1
We had similar findings (not emphasized in the publication) in our study of variant characterization at TNFAIP3. Different "monocyte" cell lines looked very distinct. "B cell" lines looked very distinct. Cell lines are often bad proxies for primary cells in terms of gene regulation.