A new study from Rockefeller's @victora.bsky.social in @cellpress.bsky.social reveals how germinal centers produce powerful antibodies through noisy rounds of mutation and selection, offering new insight into vaccine design—and larger themes in evolution.
🔗: https://bit.ly/3Sor6Ve
Aging restricts maturation of CXCL13 T follicular helper cells in hum... www.sciencedirect.com/science/arti...
The Rockefeller University
New manuscript from the lab online:
Here we define that Notch/Dll1 via Goblet cell-ILC2 acts as checkpoint preceding a protozoa-driven Tuft cell response.
Free download available here:
www.science.org/eprint/XBEHH....
Hope you will find this interesting. 😘
#theonlylabever #immunosky @science.org
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Check the #ResearchBriefing Kautilya & I wrote about our paper @natimmunol.nature.com doi.org/10.1038/s415... & enjoy some “behind the paper” highlights! 👉👉👉 rdcu.be/flbA1
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Congrats to Dr. Luke Brown on his PhD discoveries
Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice | Science www.science.org/eprint/E4WPC...
#WeekendRead! #EveryCellIsAnImmuneCell! Brown, Yipp &co show @science.org that platelet cathelicidin initiates antibacterial neutrophil-platelet lung aggregates amplified by LTB4, driving lethal immunothrombi during sepsis! LTB4 blockade maintains antibacterial functions preventing immunopathology!
Thanks to Kirsty Minton senior editor at Nature Reviews Immunology for highlighting our work! @natrevimmunol.nature.com @science.org @ucalgary.bsky.social @ucalgarymed.bsky.social
www.science.org/doi/10.1126/...
www.yipplab.com
www.nature.com/articles/s41...
A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL1…
Sepsis is an immune paradox in which host defense is necessary for survival but also contributes to organ damage and death. We defined an immunothrombosis cascade of neutrophil and platelets in the lu...
A study in Science uses intravital microscopy to analyse the septic process in real time in mouse lung, showing that immunothrombus formation is associated with early pathology and mortality but later...
#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!
Protective and pathological roles of immunothrombosis in sepsis
dlvr.it
Nature Reviews Immunology, Published online: 09 June 2026; doi:10.1038/s41577-026-01323-0A study in Science uses intravital microscopy to analyse the septic process in real time in mouse lung, showing that immunothrombus formation is associated with early pathology and mortality but later protection from disease through bacterial trapping.
Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...
