Autism subtypes identified using cross-species functional connectivity analyses
Marco Pagani et al. 🧪
@natneuro.nature.com
www.nature.com/articles/s41...
This news article is very informative and reinforces an important point: so far, there is no clinical evidence supporting umbilical cord-derived cell therapies for autism.
More broadly: there is still no clinical evidence supporting their use for any neurological condition, in adults or children.
Immune mechanisms of congenital Zika syndrome
Abhay P. S. Rathore and Ashley L. St. John
www.science.org/doi/10.1126/...
The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?
Hawley Helmbrecht et al. 🧪
link.springer.com/article/10.1...
"Profiling of human brains across lifespan shows that the frequency of NSCs declined exponentially across the first two decades of life, but stabilized thereafter, still present in the brains of donors as old as 90 years."
Microvascular hypoxia and inflammation in chronic pain syndromes
Devahuti R. Chaliha et al. 🧪
www.cell.com/trends/molec...
Our latest paper is out in the European Journal of Pain! 🎉
We show that oromucosal treatment with a cannabidiol-enriched extract modestly reduces thermal hyperalgesia in rats with chronic neuropathic pain, without affecting infiltrating immune cells or microglial cell counts in the spinal cord.
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Extracellular matrix remodelling in neurological diseases
Jessica Chi Fung Kwok & Alexander Dityatev
@natrevneurol.nature.com 🧪
www.nature.com/articles/s41...
Intravenous human umbilical cord-derived mesenchymal stem cell transplantation for ischemic stroke (MERIT): A phase 1 trial
Lili Cui et al. 🧪
@cp-cellrepmed.bsky.social
www.sciencedirect.com/science/arti...
Feeling abandoned and overwhelmed, families are turning to controversial new therapies backed by the US health secretary
This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.
www.science.org
Pagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways, respectively.
Perinatal brain injury (PBI) is a major predictor of neurological disability. Commonly associated with prematurity, infection, stroke, hypoxia-ischemia, hemorrhage, and/or toxin exposure, PBI triggers...
link.springer.com
In this opinion, we propose that compromised microvascular perfusion and inflammation
are fundamental drivers of chronic pain syndromes, with many of these conditions sharing
a common etiology involvi...
Background Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of the endocannabinoid system. Cannabis-based products hav...
Treating the immune system to repair the brain
Michal Schwartz and Tommaso Croese
www.science.org/doi/10.1126/...
Pedro Pimentel-Coelho
Pedro Pimentel-Coelho
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) hold promise as a potential therapy for ischemic stroke, but the optimal transplantation strat…
This Review outlines how the neural extracellular matrix (ECM) regulates synaptic function, memory and cognitive flexibility, and how its remodelling can contribute to both acute and chronic CNS disor...
