Don't miss out this fantastic review on mitophagy from @soleimanpourlab.bsky.social out now in @cp-trendsendomet.bsky.social!
Salvatore Fabbiano
New from us! Had a question about mitophagy but were afraid to ask? 😂
Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in
@cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D
Scott Soleimanpour
Online Now: Mitophagy in the adaptation to pancreatic β cell stress in diabetes #trends #endocrinology #metabolism
dlvr.it
Mitophagy is a crucial quality control process that preserves metabolic efficiency by selectively targeting damaged mitochondria for removal. Given the high metabolic demand of pancreatic β cells’ insulin secretion, disruption of mitophagy contributes to the mitochondrial dysfunction and β cell failure that are a common feature of both type 1 and type 2 diabetes (T1D and T2D). We review the impact of mitophagy on β cell responses to (patho)physiologic stressors that underlie the development of T1D and T2D. We examine how β cells engage mitophagy in the adaptive response to metabolic, inflammatory, and oxidative damage. We also dissect the importance of ubiquitin- and receptor-mediated mitophagy, methodological advances to quantify mitophagy in β cells, and ongoing efforts to pharmacologically target mitophagy to preserve β cell health and improve glycemic control.
