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The June 2026 issue of Trends in Endocrinology and Metabolism is online! This issue explores emerging ideas across metabolism and endocrine biology. Dive into the latest reviews and perspectives shaping the field 👇 www.cell.com/trends/endoc... #Endocrinology #Metabolism #Science

Our panel discussions at Cell Press Symposia #CSMito2026 in Glasgow next month: - Cancer as a window into mitochondrial biology - Career challenges with @ishahjain.bsky.social & Thomas Langer - Meet Cell Press editors Register here: http://dlvr.it/TSkRZL

Prolonged activation of the hypothalamic–pituitary–adrenal axis results in excessive secretion of the glucocorticoid (GC) hormone cortisol, which contributes to weight gain, increased appetite, and inflammation. GCs are essential in regulating stress responses and suppressing immune functions. They bind to the GC receptor and influence gene expression through transcriptional mechanisms. Sustained elevation of GC levels may lead to GC resistance, thereby contributing to inflammation, adiposity, and insulin resistance, which negatively impact the hepatic, cardiovascular, and renal systems. This condition is referred to as cardiovascular–kidney–metabolic (CKM) syndrome. The notable pathologies associated with GC resistance and CKM syndrome are discussed, with particular emphasis on CKM staging and potential therapeutic strategies for individuals with cardiometabolic dysfunction.

The epiphyseal growth plate is the key target of growth hormone (GH) therapy. Although growth plate stem cells are well defined in mice, their presence in humans was unclear. Using rare surgical specimens, the study by Chu et al. reveals conserved, GH-responsive stem cells in the human pubertal growth plate.

Androgen deprivation is assumed to boost antitumor immunity—but Lee et al. overturn this logic in glioblastoma, showing that androgen loss activates a microglial inflammasome–hypothalamic–pituitary–adrenal axis cascade that elevates glucocorticoids and attenuates T cell function. The study reveals how organ context reverses endocrine control of tumor immunity.

Early life is a critical window during which microbes shape immune maturation, nutrient handling, and long-term metabolic health. Although fungi represent a minor proportion of the gut microbiome, emerging evidence suggests they exert a disproportionate influence. In this review, we synthesize current gut mycobiome knowledge during pregnancy and infancy, including ecological assembly, maternal and environmental sources, and links to early metabolic phenotypes. Recent studies on human cohorts and gnotobiotic mice demonstrate that specific fungal species can causally alter adiposity, adipose immune architecture, and bacterial function. We also highlight major knowledge gaps, including questions around true colonization, fungal activity, strain-level transmission, and the molecular basis of fungal–bacterial–host interactions. These findings position the early-life mycobiome as a promising frontier for discovery in metabolic development.

Inborn errors of redox metabolism (IERM) are a growing yet poorly defined group of disorders, limiting understanding and treatment. We propose a dichotomous classification: primary IERM, involving genetic defects in redox pathways, and secondary IERM, where reactive oxygen species-mediated damage arises from other metabolic defects. This framework aims to guide future research.

Hippo signalling is increasingly recognised as an important regulator of metabolic adaptation rather than solely a pathway controlling organ size and growth. This review examines how nutrients, hormones, and energy stress regulate Hippo-Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) activity, and how Hippo signalling, in turn, rewires glucose, lipid, amino acid, and nucleotide metabolism. We highlight emerging concepts, including metabolite-specific checkpoints, tissue-specific Hippo functions across metabolic organs, and the context-dependent roles of Hippo signalling in obesity, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease/steatohepatitis, cardiometabolic disease, and cancer. We also discuss how this bidirectional Hippo–metabolism axis is opening new therapeutic opportunities, while underscoring that effective translation will require cell-type- and disease-stage-specific targeting.

Excited to see our review out in @cp-trendsendomet.bsky.social! Great team effort and lots of fun to dive into how #islets form and how we can use this knowledge for #diabetes therapy. @mireiamoli.bsky.social @ckarampelias.bsky.social @heikolickert.bsky.social www.sciencedirect.com/science/arti...

Wonderful to see this out! Thank you @cp-trendsendomet.bsky.social and @cellpress.bsky.social for inviting me to contribute to this collection celebrating mitochondria research and global experts. I am honored to have our work featured! @aibnatuq.bsky.social www.sciencedirect.com/science/arti...