Pediatric neuro-oncologist, Asst Prof U-Michigan | Cancer researcher | RNA & ribosome enthusiast | Broad Institute, DFCI alum | book & music & tea lover | Dad | Views are mine (he/him). https://prensnerlab.org
John Prensner
Loading...
For all #DarkProteome #Microprotein #RiboSeq enthusiasts- come join me at #EACR if you are here!
I will be talking in the Dark Proteome session today at 2pm!
Combined Optical Pooled Screens and Perturb-seq!
Great new work by Romain Lopez & Taka Kudo. This is one of a series of papers from our lab (here, with Aviv Regev) using perturbations to interpret human genetics; a key revelation for me is how transferable the mouse perturbs are to human genetics.
New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing?
Check out this work led by postdoc Jingkun Zeng:
www.biorxiv.org/content/10.6...
#a2council 🧵 A brief history of Ann Arbor isn't a small town anymore
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...
Very happy to share our @cbitoulouse.bsky.social perspective article with @jzanet.bsky.social team in @proteinsociety.bsky.social Protein Science: “Sketching microprotein portraits”.
onlinelibrary.wiley.com/doi/10.1002/...
poke @johnprensner.bsky.social @thomasmartinez.bsky.social
#microprotein
RNA imbalance as a hallmark of cellular ageing rdcu.be/fikJl
😀
see also www.nature.com/articles/s41...
Wow what a blockbuster PhD paper by @claradure.bsky.social with @sendoellab.bsky.social . It is a must read!
👇
🦠💡 Bacteria have millions of secret weapons against viruses!
Researchers used AI to uncover millions of new bacterial proteins likely involved in antiviral defense — suggesting immunity genes make up ~1.5% of the genome, 3× more than thought.
🔗 www.pasteur.fr/en/research-...
@audeber.bsky.social
www.biorxiv.org
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
Nature Cell Biology - This Perspective highlights the failures of an ageing cell in properly maintaining mRNA health at the various steps of the mRNA life cycle that result in vulnerability to...
