It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
