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High/moderate-efficacy DMTs cut sNfL ~40% and are associated with bigger gains in disability & relapse reduction; compared to first-line therapies. sNfL decline tracks EDSS/motor improvement (age-independent), but not psychiatric outcomes → biomarker potential. Paper below ⬇️⬇️
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Disease-modifying therapies (DMTs) are widely used to manage multiple sclerosis (MS), but their effects on serum neurofilament light chain (sNfL), par…
www.sciencedirect.com
Tracking the invisible: Impact of disease-modifying therapies on serum neurofilament light chain and clinical outcomes in treatment-naïve multiple sclerosis
Journal of Neuroimmunology