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Journal of Neuroimmunology
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mmune-checkpoint-inhibitors related CNS #neurotoxicity can mimic paraneoplastic and autoimmune encephalitis, making diagnosis challenging. High-risk anti-neuronal antibodies may predict poorer outcomes, while post-ICI meningoencephalitis responds well to corticosteroids.
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🧠👶🏻 Upcoming release of a special issue dedicated to Pediatric Neuroimmunology.
Call for paper, check details below and submit your work:
sciencedirect.com/special-issue/…
IRE1α/ASK1 signaling drives ER stress–mediated neuronal 🧠 apoptosis via the p38-CHOP pathway and caspase-3 activation.❌Blocking this pathway 😘➡️reduced infarct size & neurological damage: a promising therapeutic target for stroke.
Check out the paper 👇
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High/moderate-efficacy DMTs cut sNfL ~40% and are associated with bigger gains in disability & relapse reduction; compared to first-line therapies.
sNfL decline tracks EDSS/motor improvement (age-independent), but not psychiatric outcomes →
biomarker potential.
Paper below ⬇️⬇️
Persistent CNS inflammation in HIV continues despite ART. ↑ MMP-2 & MMP-9 in CSF point to localized brain inflammation. No differences across HIV subtypes or Tat variants. #HIV #NeuroHIV
Check the paper below 👇 www.sciencedirect.com/science/arti...
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1 in 5 neurosarcoidosis exhibit comorbid autoimmune disease, family history of autoimmunity, or nonspecific autoantibody seropositivity. These overlapping features represent potential sources of diagnostic ambiguity and may impact treatment strategies.
Check the paper below 👇
Soluble c-Met ↑ in CSF & plasma, CSF c-Met links to NfL/GFAP, plasma ADAM10 ↓. Suggests compartment-specific c-Met shedding in early MS. #MultipleSclerosis #Biomarkers #Neuroinflammation
Check the paper👇:
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FoxF2, a key regulator in remyelination in progressive MS 🧠
FoxF2+ Astrocyte links to TGFβ signaling and coordinates myelin repair, immune response, and metabolism. Its loss disrupts regenerative gene networks.
#MultipleSclerosis #Neuroscience
Check out the paper below 👇
sciencedirect.com
Journal of Neuroimmunology
Journal of Neuroimmunology
Journal of Neuroimmunology
The hepatocyte growth factor (HGF)/c-Met pathway plays an important role in several inflammatory conditions, regulating phenotypic plasticity within b…
