Professor at UCSF. Molecular/cellular mechanisms of brain disease. Functional Genomics. Diversity & Inclusion. š³ļøāš he/him
Martin Kampmann
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Congratulations on passing your qualifying exam, Reet Mishra! š¾
#kampmannlabproud
Kampmann lab Halloween costume this year:
Revenge of the lab rats
(Including several KO mice)
Happy š»š
Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
Apply by Oct 15 - please spread the word!
Very honored to receive this year's Byers Award in Basic Science!
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.
www.ucsf.edu/news/2025/07...
Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/
Exciting work, thanks for sharing!
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
@kampmann.bsky.social @ivlrose.bsky.social
www.nature.com/articles/s41...
Martin Kampmann
Martin Kampmann
Martin Kampmann
Martin Kampmann
Martin Kampmann
Addgene
Martin Kampmann
Martin Kampmann
Martin Kampmann
Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05702
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4
ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimerās
disease, and that electr...
Plasmid pAP215.rAAV.mU6-sgRNA.Handle.EF1a-mTagBFP2 from Dr. Martin Kampmann's lab contains the insert mU6-sgRNA, Handle sequence, EF1a-mTagBFP2 and is published in Nat Neurosci. 2025 Aug 22. doi: 10.1...
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex...
TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments.
More below š
asamelson
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4
ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimerās
disease, and that electr...
