Postdoc in the Stark lab at IMP, Vienna | PhD in the Bickmore lab at MRC_hgu, Edinburgh | gene regulation, enhancer biology 🧬 | sport enthusiast 🏃🏼♀️🏋🏻♀️🏇
Giovanna Weykopf
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Distal and proximal transcriptional activation may not be so different - check out the latest pre-print from @eliasfriman.bsky.social
Very happy to have contributed a small part and seen this story develop!
Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social
www.biorxiv.org/content/10.6...
New pre-print identifying 29 Covid GWAS variants that drive allele-specific activity in a functional genomics screen in lung cells, from @gweykopf.bsky.social and
@eliasfriman.bsky.social @simonbiddie.bsky.social
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
@uk-fgx.bsky.social
Giovanna Weykopf
Wendy Bickmore
Wendy Bickmore
Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/
www.biorxiv.org/content/10.6...
