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...but 4 Gy RT is nontoxic with robust local dx control. www.nature.com/articles/s41... #lymsm #medsky
Hans IHC vs GEP for DLBCL COO classification #EHA2026 Large meta-analysis (19 studies, 2247 tumors) to eval noninferiority of Hans IHC to GEP. Estimated accuracy: - Hans IHC 90% - pooled GEP 95% - 4.5% difference met noninferiority margin - sens 6.5% / NPV 6.4% library.ehaweb.org/eha/2026/eha...
Good efficacy for challenging disease + improved QoL in pall setting. #lymsm www.asco.org/abstracts-pr...
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Blood Cancer Journal - Prospective phase II study of frontline Helicobacter pylori eradication therapy for early-stage extragastric mucosa-associated lymphoid tissue lymphoma
www.nature.com
Prospective phase II study of frontline Helicobacter pylori eradication therapy for early-stage extragastric mucosa-associated lymphoid tissue lymphoma - Blood Cancer Journal
www.asco.org
EHA Library; Alizadeh A. May 12 2026; 4210285;
library.ehaweb.org
Fixed-duration subcutaneous (SC) mosunetuzumab (Mosun) in elderly/unfit patients with previously untreated diffuse large B-cell lymphoma (DLBCL): Interim analysis and patient-reported outcomes (PROs) ...
A SYSTEMATIC ASSESSMENT OF DLBCL CELL-OF-ORIGIN CLASSIFICATION... by Ash Alizadeh
Fixed-duration SC mosun older/unfit 1L DLBCL #ASCO26 - median age 83 (71-101!), 53% IPI 3-5 - ORR 74%, CR 59% - 12-mo PFS 71%, OS 75% - CRS 12% (all G1-2), 49% infx (16% G3), 8% G5 AEs - PROs: 53% w/ improvements in lymphoma sx #lymsm
Supports Hans IHC as a practical & reliable procedure for COO classification in DLBCL. Particularly important with pola non-GC data. #lymsm
Frontline H. pylori eradication for extragastric ENMZL #lymsm - 26 pts, 46% conjunctival, 19% parotid - ORR 65% (CR 39%, PR 27%), time to CR 6 mos - 7-yr EFS 77%, OS 96% - HP+ dx with better responses (obv), t(11;18) less responses Provocative evidence re: HP+ in non-gastric sites...