Studying phagocytosis and cell-autonomous defences against mycobacteria
Soldati Lab
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📣 Happy to share our new chapter in Live Biological Imaging Across Scales! We discuss how to explore membrane damage responses using Dicty and high-throughput single-cell analyses 👀. Shout-out to @angieprrt.bsky.social and the team onlinelibrary.wiley.com/doi/10.1002/...
How does the mycobacterial vacuole go from damage that can still be repaired to full rupture? 👀
Our new preprint shows that EsxA and PDIM act sequentially: EsxA initiates repairable lesions, and PDIM helps push them past host repair capacity toward cytosolic escape.
doi.org/10.64898/202...
What if better TB therapies start with an amoeba? Our recent chapter highlights the Dd–Mm model as a versatile platform to study infection and explore host-directed therapies. Check this out ⤵️
@nabilhanna3.bsky.social www.sciencedirect.com/science/chap...
Congrats to @michard-celine.bsky.social who led this work. Thanks to all the collaborators: @angieprrt.bsky.social and @mel-foulon.bsky.social from @sciencesunige.bsky.social, and Hendrik Koliwer-Brandl & Hubert Hilbi at University of Zurich.
🚨 Preprint alert 🚨
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
🎉 Big news! Last Saturday, Thierry was awarded the Egon Naef Foundation Prize for in vitro research 🏆 A wonderful recognition of his innovative work throughout his career developing alternatives to animal testing 👏
www.unige.ch/sciences/chi...
@sciencesunige.bsky.social
Soldati Lab
Soldati Lab
Soldati Lab
Soldati Lab
Soldati Lab
Soldati Lab
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?
Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.
www.nature.com/articles/s41...
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🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
📣 After 5 years, the last paper from my PhD is finally out in #ScienceTranslationalMedicine!
We show that sustained tissue inflammation drives disease progression in #Buruliulcer. And targeting it alongside antibiotics can accelerate healing.
www.science.org/doi/10.1126/...
