Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...
🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells?
🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs
More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens
Feng et al. present the first genome-scale CRISPR interference perturbation map with
scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering
population-scale CRISPR pe...
Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible!
Britta Velten
Annique Claringbould
Take a look at the data yourself in our interactive browser www.sanger.ac.uk/tool/crispri... and read our paper for lessons learnt on the design of population- and genome scale CRISPR screens
A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens 👇 www.biorxiv.org/content/10.6...
Auszeichnung für Heidelberger Datenwissenschaftlerin: Britta Velten wird für innovative Verfahren für die Analyse von komplexen Datensätzen aus den Lebenswissenschaften mit dem Early Excellence in Science Award ausgezeichnet www.uni-heidelberg.de/de/newsroom/...
#uniheidelberg #lifescience
With @leopoldparts.bsky.social and @oliverstegle.bsky.social we comprehensively mapped CRISPRi responses in iPSCs identifying protein complexes as nexus for transcriptional changes and made a first step towards population-scale CRISPR screens to dissect genetic modulation of perturbation responses
