Tenure-Track-Professor for Multifactorial Data Analysis and Machine Learning in the Life Sciences @UniHeidelberg
https://velten-group.org/
Britta Velten
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A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens 👇 www.biorxiv.org/content/10.6...
Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible!
Was fun to be part of this!
Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...
Take a look at the data yourself in our interactive browser www.sanger.ac.uk/tool/crispri... and read our paper for lessons learnt on the design of population- and genome scale CRISPR screens
With @leopoldparts.bsky.social and @oliverstegle.bsky.social we comprehensively mapped CRISPRi responses in iPSCs identifying protein complexes as nexus for transcriptional changes and made a first step towards population-scale CRISPR screens to dissect genetic modulation of perturbation responses
