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Are PolyQ Inclusion Bodies detrimental or protective in Huntington’s Disease? The amazing Walaa Oweis in my lab shows they are protective in human iPSC-derived neurons, confirming Finkbeiner’s observation in rodents. She further found that ATF3 is required for their formation. 🔥🔥🔥 rdcu.be/fbjil
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ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection - Cell Death & Differentiation
Cell Death & Differentiation - ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection
www.nature.com
Eran Meshorer