Extracellular environment stabilization of stem cell state identity via KDM3A👇🔥
Beautiful work
This new method, BLISS, to detect single molecule fluorescent bursts revealed the “hyperdynamic” fraction of HP1a we previously observed in pluripotent stem cells. Check it out👇🔬🔥
Check out this new Review Article in TiG by the amazing Elad Dvir, a joint student of the Shifman and Meshorer labs👇👇
Functional fertile sperm from mouse embryonic stem cells👇🔥
And today Shalhevet’s Flashtalk about SCA3 concluded our lab’s presentations. Kudos everyone!⚡️🧬🔬
Are PolyQ Inclusion Bodies detrimental or protective in Huntington’s Disease? The amazing Walaa Oweis in my lab shows they are protective in human iPSC-derived neurons, confirming Finkbeiner’s observation in rodents. She further found that ATF3 is required for their formation.
🔥🔥🔥
rdcu.be/fbjil
🔥Flashtalks and posters in ILANIT FISEB meeting today by Shira Siegel, Shira Horev, Riki Masar, Eden Mishne and Avital Pushett🔥
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Eran Meshorer
Cell Death & Differentiation - ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Our Trends in Genetics review discusses how variant effects, genetic background, environment, and developmental noise may all contribute.
www.cell.com/trends/genet...
authors.elsevier.com/a/1mxFv_3rsx...
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
🔥Flashtalks and posters in ILANIT FISEB meeting today by Shira Siegel, Shira Horev, Riki Masar, Eden Mishne and Avital Pushett🔥
Announcing SMART Genome Symposium: From Structure to Function !
📅 October 14–16, 2026
Focus: 3D genome organization | Chromatin dynamics | Computational modeling
Register now symposia.smart.org.cn/sym/event/Fu...
#SMARTSymposia #SMARTshenzhen #Genome #Genomes #Biophysics
Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells. @science.org
"In vitro gametogenesis could be beneficial in various settings ranging from human reproduction to helping with recovery of endangered species."
www.science.org/doi/10.1126/...
Our H1 paper is out #ScienceAdvances:
www.science.org/doi/10.1126/...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
www.biorxiv.org/content/10.6...
Single-molecule fluorescence bursts of FP-tagged proteins are achieved in live cells using a new method, BLISS, exposing a rare subpopulation of heterochromatin protein 1alpha dense clusters in undifferentiated embryonic stem cells.
Carmelo Ferrai
Sagiv Shifman
Eran Meshorer
With the advent of sequencing technologies in recent years, hundreds of high-confidence
risk genes have been implicated in neurodevelopmental disorders (NDDs). However, individuals
carrying pathogenic...
Proper differentiation of gonadal somatic cells is crucial for sex determination and the production of sex hormones and gametes, and reconstituting this process in culture would both deepen our unders...
