Assistant Professor at Caltech | Chemical Biologist
morsteinlab.caltech.edu
Johannes Morstein
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Excited to share the first study from the Morstein Lab on a new approach that enables selective editing, tagging, and visualization of mammalian lipids
www.biorxiv.org/cgi/content/...
#chembio #lipidtime @caltech.edu @caltechcce.bsky.social @harayamajrlab.bsky.social @logan-tenney.bsky.social
www.biorxiv.org
Johannes Morstein
We extended this approach to alkylglycerols and sphingosines to selectively access subsets of ether lipids and sphingolipids
Systematic chemical modifications enabled new and more selective metabolic incorporation, allowing to target subsets of glycero(phospho)lipids.
Together, our study shows that lipid tail structure is a programmable determinant of metabolic fate and that this principle can be leveraged to selectively route substrates through endogenous lipid metabolic networks enabling selective editing and functionalization.
We started out by mapping the structural dependence of lipid metabolism using isotope tracing, showing that lipid tail structure directs metabolic fate across the lipidome (Figure 1)
Finally, we introduced bifunctional lipid probes that enable selective labeling and visualization of distinct lipid classes in living cells
Johannes Morstein
Johannes Morstein
Johannes Morstein
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
Johannes Morstein
BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!
Johannes Morstein
I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...
Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.
