There indeed is a lot of papers on microbial defense/anti-defense systems coming out that were run under conditions that are so foreign that they leave you wondering if that's really how they work.
We do need to test these systems more! 🧪🦠🔬
Danillo O. Alvarenga
Our new paper on archaeal anti-CRISPRs is out in
@Nature (@SpringerNature)! 🔗 rdcu.be/eh1Ma
Using a native virus–host model (SIRV2–S. islandicus), we show that overexpression in foreign hosts can lead to false positives.
🧵(1/n) #CRISPR #archaea #antiCRISPR #virology
