Empowering scientists with tools that reveal crucial insights not available before, at the molecular and cellular level | Dynamic single-molecule & Cell Avidity
LUMICKS
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If your work involves DNA-binding proteins, this kind of sensitivity and speed could significantly accelerate your research!
Read the paper: www.nature.com/articles/s41...
Subtle differences in binding location, dynamics, and off-target behavior in DNA-protein interactions are difficult to resolve traditionally.
A recent @nature.com publication from David Ruedalab highlights C-Trap to quickly distinguish off-target activity of Cas9 from its high-fidelity variants 👇
Congratulations to all the authors!🎉
Demo: many C-Trap users want to do cell mechanobiology experiments on the C-Trap. Our scientists recorded this video showing what a live cell membrane pulling experiment looks like on the C-Trap. Details of the workflow and key highlights are in the video captions: www.lumicks.com/university/v...
Video guide for advanced features of the bright-field camera: 👉 How to record the bright-field camera images along with the matching timeline data. 👉 How to crop the camera field of view, and increase the camera framerate. www.lumicks.com/university/v...
Nuclear Extracts: we recently published an article in LUMICKS University introducing the prep and use of nuclear extracts for DNA-protein interaction experiments on the C-Trap. From extraction to assessment of fraction purity, to labelling and dilution on the C-Trap: www.lumicks.com/university/a...
Very important to highlight: thank you for the team work to the @sheffielduni.bsky.social power team: @mattdnewton.bsky.social, @alicepyne.bsky.social and Ruby Peters.
