What determines cell-cycle-dependent loading of human CENP-A?
Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows @andrea-musacchio.bsky.social and coworkers to identify determinants, including structure of the M18BP1 SANTA domain
link.springer.com/article/10.1...
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The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
