I will be presenting a poster in the Ub and Friends Symposium (poster no.39). I am eager to discuss our latest work from @fletcherlab.bsky.social and looking forward to attending the conference between 29-30 April in Vienna!
Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape
Excited to share our new paper uncovering how FANCD2 recognises various DNA repair proteins www.biorxiv.org/content/10.6... @hw1o9.bsky.social
Delighted to share our article on the functional expansion of OAS2 via alt. splicing.
link.springer.com/article/10.1...
A tour de force from PhD student Emma Davies and friends.
Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear.
Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA.
www.cell.com/molecular-ce...
Online now! Online now! Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins #chembiol
Alice Wicks
Cell - a Cell Press journal
Squair et al. show that ZNFX1 restricts ssRNA virus replication by integrating SF1
helicase activity with dual E3 ligase mechanisms. ATP-dependent RNA binding activates
E3 function, driving self-propa...
Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...
