Online now! Online now! Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins #chembiol
In this study, Gustafsen et al. introduce SORTACs, a PROTAC-like strategy that hijacks the sortilin-progranulin pathway to drive lysosomal degradation of extracellular proteins. SORTACs enable modular, small molecule and biologic degraders, expanding targeted protein degradation beyond the cytosol to previously inaccessible extracellular targets.
