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New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6
1mo
doi.org
Huge congratulations to @mfdspicer.bsky.social, PhD student in our lab, for winning the Best Poster Prize at the 2nd Spatial Genome Organization Conference! 🎉 A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏 @fusionconf.bsky.social #SGO25
7mo
Gerlich Lab
Excited to share this work done during my PhD here in Vienna! We show how chromatin compaction prevents the release of fragmented DNA in apoptosis, and use new tools to study the mechanism of compaction itself. See our summary/"bluetorial" below & our preprint here: www.biorxiv.org/content/10.6...
Chuffed to have defended my PhD thesis! Big thanks to @danielgerlich.bsky.social for all his support and guidance; and to the wonderful @gerlichlab.bsky.social, @imbavienna.bsky.social & @viennabiocenter.bsky.social for being an incredible scientific home these past few years. On to the next :)
5d
3mo
Gerlich Lab
www.biorxiv.org
🚨 New Science paper from the Gerlich lab! The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
6mo
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
6mo
3mo
Max Spicer
Max Spicer
www.science.org
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
www.biorxiv.org
Gerlich Lab
Institute of Molecular Biotechnology
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Please RT https://training.vbc.ac.at/summer-school/
7mo
Federico Teloni
Vienna BioCenter Scientific Training