CREsted is finally out! You can find the article, together with a summarizing Research Briefing, in thread. 🦎
... and to @steinaerts.bsky.social for his guidance throughout the project.
Really amazing work and a big effort by Olga, Alex, Julie, Koen and many others. Check it out for sure!
Compared to the preprint we added robustness analyses and more benchmarking of options within CREsted and of CREsted features (like motif identification) to traditional methods. We also aimed to position it well in the landscape of sequence-based modeling methods.
Fun fact: CREsted is named after the great crested newt, which has a crested back resembling scATAC peaks. This was inspired by the (alpine) newts I occasionally encounter in my parents' garden 🤗