Congrats to Julian and others from @ramlabuw.bsky.social on this cool work that finds that the loss of the RNA-binding protein CELF2 leads to accumulation of endogenous RIG-I ligands! #RNA #innateimmunity #IFNs
Nandan Gokhale
CELF2 suppresses immunostimulatory endogenous RNAs that activate the RIG-I-MAVS pathway in macrophages, preventing type I IFN-signature. Congrats to Julian Smith, Olivia Kern, and all the co-authors for their hard work! #innateimmunity #dsRNA #IFN
www.biorxiv.org/content/10.1...
