Postdoc at Siepel Lab, CSHL
Statistical genetics, phylogenetics, and optimization
Nurdan Kuru
#BoG25 at home - CSHL
Nurdan Kuru
A gene called NOVA1 may be part of the solution to the mystery of how our ancestors evolved language. Here's my story about mice with strange squeaks. [Gift link] nyti.ms/3XuVehN đ§Ē
NOVA1, a neuron-specific RNA binding protein & splicing factor, likely impacted language function in human evolution. Human NOVA1 is unique (vs mammals, Neanderthals), & it changes vocalization in CRISPRâd mice!
TY @NatureComms @RockefellerUniv team, collaborators @erichjarvis @asiepel labs
đ§ĩđ
All data generated in this study and all benchmark analysis scripts and source codes for PHACE are available at github.com/CompGenomeLa...
Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and OgÃŧn Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution.
Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!
Carl Zimmer
A phylogeny-aware approach to detecting amino acid coevolution: PHACE. Instead of relying on sequence alignments only, it maps substitutions onto evolutionary trees and accounts for shared ancestry. A nice step toward more accurate models of protein evolution and structure.
Nurdan Kuru
Nurdan Kuru
Bob Darnell
Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and OgÃŧn Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution.
Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!
Nurdan Kuru
Caroline Puente-Lelievre
Coming up on August 5 đī¸
Nurdan Kuru @nurdankuru.bsky.social shares phylogeny-aware methods for variant effect prediction.
Ferdy van Geest dives into MCT8 variants & thyroid disease. Computational meets clinical! #Genetics #RareDisease #MedicalGenetics âšī¸ www.varianteffect.org/seminar-seri...
A new study suggests that the NOVA1 gene may have been a key player in the evolution of human language.
