A phylogeny-aware approach to detecting amino acid coevolution: PHACE. Instead of relying on sequence alignments only, it maps substitutions onto evolutionary trees and accounts for shared ancestry. A nice step toward more accurate models of protein evolution and structure.
Caroline Puente-Lelievre
Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and Ogün Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution.
Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!
Nurdan Kuru
@nurdankuru.bsky.social & Adebali present PHACE, a phylogeny-aware coevolution algorithm that maps amino acid substitutions onto a phylogenetic tree to detect molecular coevolution.
🔗 doi.org/10.1093/molbev/msaf150
#evobio #molbio #phylogenetics
