Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...
This was a collaborative effort with the omnipotent Stefan Pfeffer and @chillzaa.bsky.social people (e.g. @sophiekopetschke.bsky.social).
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
Thrilled to share our recent discovery from the Agrawal and Ojha Labs: an Actinobacteria-specific ribosome hibernation factor bound to Mycobacterium tuberculosis ribosomes isolated from biofilms. www.biorxiv.org/content/10.1...
@cryoempapers.bsky.social @mycobacterium.bsky.social