Clinical Science PhD at UMich | Incoming Intern at Harvard Medical School/McLean Hospital | NSF GRFP | Social Perception & Decision-Making in Psychosis via Computational Modeling & 🧠
Carly A. Lasagna
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A study in @nature.com shows that while complex traits are polygenic in population at large, they have distinct architecture at tails, where rare variants of large effect act as key drivers. Not a surprising finding but neat to see it demonstrated in large UK Biobank cohort across traits & methods.🧪
Enjoying the Barcelona APS and seeing all the @um-src.bsky.social data being presented @psychscience.bsky.social
This one👇🏻 because: 1) the cognitive and brain sciences and AI/ML have typically focused on problem solving and there’s not nearly as much discussion of how we find important problems or what makes a problem worthy of attention; 2) the paper could use more citations.
link.springer.com/article/10.1...
Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common ...
It is my mission in life to spend 15 minutes writing footnotes that maybe 3 people will read.
Thinking about how this might go
Listener: My chains aren't converging
Andrew: Your model is bad
Aki: Your parameterization is bad
Richard: The Buddha teaches us that numerical integration is suffering
Harrison Ritz
Simon Fisher
Tip for junior authors: "Filling a gap" is not a theoretical motivation. Before submitting a paper, ask which theory or model predicts a different pattern from yours. If no rival prediction is at stake, you're likely testing an effect, not a theory. #cogpsyc #AcademicSky🧪
