A study in @nature.com shows that while complex traits are polygenic in population at large, they have distinct architecture at tails, where rare variants of large effect act as key drivers. Not a surprising finding but neat to see it demonstrated in large UK Biobank cohort across traits & methods.🧪
Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common ...
