In this preregistered study we use random-intercept cross-lagged panel models to disentangle between- and within-person associations between youth psychopathology and white matter trajectories. We also examined whether these associations differ for youth with high vs low parental psychopathology.
We found small symptom-specific cross-domain associations linking self-reported internalizing problems to within-network connectivity of the Frontoparietal, Default, and Salience Network, as well as between-network connectivity between the Default and Salience network.
Our findings indicate that the heterogeneity of internalizing problems might be partially reflected in functional connectivity patterns.
In this collaborative work, we merged symptom networks with functional connectivity networks and examined symptom-specific associations between internalizing problems in youth and functional connectivity.
An overview of the findings can also be found on this poster: