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This work is the product of an outstanding multidisciplinary team operating across multiple countries. Special congrats to Safe Khan, lead author of the study. And congrats to all authors and supporting institutions! doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social
#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social
Read the spotlight here: focalplane.biologists.com/2026/01/13/i... Read the whole paper here: www.nature.com/articles/s41... @crick.ac.uk @psich.bsky.social
Here's a spotlight article on our recent study! Tissue ultrastructure can be resolved with X-rays, which impacts not only how we can study neuronal circuits but soft tissues more generally. Kudos to Ana Diaz, @adrianawanner.bsky.social, @andreas-t-schaefer.bsky.social and all authors.
What is psychosis and how can we treat it? Crick group leader @kathaschmack.bsky.social explains how her lab is working to uncover new ways to treat psychosis by finding its biological roots. youtu.be/EUb3_5ecatU
Method of the Year 2025: In his Comment, Moritz Helmstaedter looks into the future of connectomics and the feasibility of scaling up to larger brains. www.nature.com/articles/s41...
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...
Excited to see our paper describing a stereotyped receptor map for smell (led by @davidhbrann.bsky.social ) out in the world! See below for short thread with open access link to paper www.nytimes.com/2026/04/29/s...
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X-ray phase contrast tomography can efficiently image brain tissue at subcellular resolution. Critical point drying allows a gentle replacement of interstitial material by air, enhancing X-ray phase c...
doi.org
Critical point drying of brain tissue for X-ray phase-contrast imaging
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News
focalplane.biologists.com
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane
YouTube video by The Francis Crick Institute
A Crash Course in Psychosis – with Katharina Schmack
Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.
www.nature.com
youtu.be
Optimism for abundant whole-brain connectomes and connectomic screening - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
www.nature.com
Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
www.nytimes.com
Scientists Unveil ‘Long Lost’ Map for Smell
Carles Bosch
Carles Bosch
Carles Bosch
Carles Bosch
The Francis Crick Institute
focalplane.biologists.com
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane
Nature Methods
Nature Methods
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Datta Lab
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
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Moritz Helmstaedter
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane
focalplane.biologists.com
FocalPlane
Current Biology