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TSA treatment may induce cellular and structural memory !! Happy to have been part of this beautiful story, lead by @fpaldi.bsky.social in Giacomo Cavalli's lab. Now published in @natgenet.nature.com 👏. www.nature.com/articles/s41...
4mo
Acute perturbation of histone acetylation induces changes in chromatin organization that are only partially reversed once the perturbation is removed and are associated with transcriptional memory eff...
www.nature.com
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding - Nature Genetics
Daniel Jost - Physical Biology of Chromatin group