CNRS Research Professor - Group Leader at Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon.
Physical biology of chromatin: modeling the spatio-temporal dynamics of eukaryotic genomes.
Daniel Jost - Physical Biology of Chromatin group
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🚨SUMOylation regulates the formation and function of Polycomb foci. New preprint from Cavalli lab where we performed modeling: SUMOylation regulates the PRC1 self-attractions mediating PcG condensate. Look at the preprint 👇https://www.biorxiv.org/content/10.64898/2026.02.05.704038v1
TSA treatment may induce cellular and structural memory !! Happy to have been part of this beautiful story, lead by @fpaldi.bsky.social in Giacomo Cavalli's lab. Now published in @natgenet.nature.com 👏.
www.nature.com/articles/s41...
Great collaboration with Yvert's lab on the kinetic characterization of a light-inducible Cre recombinase. This is the basis of future exciting works. Stay tuned 😉 journals.biologists.com/bio/article/...
Our work on the interplay between loop extrusion and chromatin mechanics is finally out in @physrevresearch.bsky.social . Congrats @hosseinsalari.bsky.social for the hard work ! 👏
journals.aps.org/prresearch/a...
Thanks also to @lucagiorgetti.bsky.social and @djost-physbiol.bsky.social for the invitation and for putting together a very interesting themed issue - the other reviews in the issue can be found here
www.sciencedirect.com/special-issu...
Daniel Jost - Physical Biology of Chromatin group
Happy to share our review of the past, recent, and future applications of synthetic genomics in studying the 3D functional organization of chromosomes, a set of approaches that are gaining momentum!
www.sciencedirect.com/science/arti...
Happy to share our new review!
Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy
www.sciencedirect.com/science/arti...
This collection summarizes key aspects of our current experimental and theoretical understanding of eukaryotic genome folding and its relationship with the molecular processes governing cell fate. Ove...
The role of genome 3D organization for fundamental chromatin processes, such as long-range promoter-activator regulatory interactions, remains ambiguo…
Summary: We characterize the properties of LiCre, which, in response to blue light, can switch on or off whatever gene is close to a specific DNA sequence called LoxP.
Acute perturbation of histone acetylation induces changes in chromatin organization that are only partially reversed once the perturbation is removed and are associated with transcriptional memory eff...
Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social
Chromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop ex...
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...
Ranjith Padinhateeri
Daniel Jost - Physical Biology of Chromatin group
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...
