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Disruption of aquaporin-mediated water efflux leads to excessive HEC swelling and rupture, as shown here in this movie, ultimately reducing HSPC production. (Green cells are gata2b+ cells.)
By coupling Piezo1-dependent Ca signalling to VRAC activity and aquaporin-mediated water efflux, HECs resolve the mechanical conflict between actomyosin-driven rounding and membrane integrity.
We propose that, in addition to transcriptional programs, successful hematopoietic stem and progenitor cell (HSPC) extrusion from the dorsal aorta requires modulation of intracellular pressure through coordinated ion flux and water transport.
Latest preprint from @phnglab.bsky.social @riken-bdr.bsky.social ! We show cellular hydraulics as a determinant of hemogenic endothelial cell (HEC) survival during endothelial-to-hematopoietic (EHT) transition. www.biorxiv.org/cgi/content/... #mechanobiology #zebrafish #endothelialcells