I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts Karen Grimes and Hyobin Jeong and co-lasts Andreas Trumpp, Jan Korbel and Ashley Sanders 🎉 🎊 5/5
We integrated single-cell resolution structural variants, nucleosome occupancy, gene expression and surface proteins to study subclonal growth patterns in complex karyotype AML patient samples 🧬 2/5
In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜 4/5
For example, in one patient the sublclone driving relapse had a seismic amplification, upregulated DNA damage response and it also engrafted in mice. We could even see cell-to-cell differences in the copy-number states of the seismic amplification! 🌋 3/5
Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻🔬
They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5
www.nature.com/articles/s41...
Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic
www.nature.com/articles/s41...
Aino-Maija Leppä
Aino-Maija Leppä
Aino-Maija Leppä
Aino-Maija Leppä
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
Aino-Maija Leppä
Nature - Characterization of single neurons reprogrammed by pancreatic cancer
Researchers from the Crick, @dkfz.bsky.social and the German Red Cross Blood Donation Centre have found beneficial genetic changes that arise in the blood stem cells of people who regularly donate blood cells.
www.crick.ac.uk/news-and-fea...
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
