1/n: Excited to share our new preprint. We find that Dorsal transcription factor hubs exhibit gene-specific biophysical properties that tune transcriptional output. Read here: www.biorxiv.org/content/10.1.... Project was led by amazing graduate student Samantha Fallacaro (not on bsky)
Big welcome to the lab to physicist turned quantitative biologist Beth Westbrook @bethwestbrook.bsky.social! Beth did her PhD in Jonathan Chubb’s lab at UCL and has been very interested in how fate transitions are coordinated. We are lucky she joined our lab for her postdoc!
A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell!
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
So excited for this new chapter and honoured to have been invited to join such a talented team!
Cool work from Sarah Bray's lab at Cambridge looking at Notch-induced transcription hubs:
www.biorxiv.org/content/10.1...
from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.
Mir Lab
Santos lab
Santos lab
F. Javier de Haro Arbona
F. Javier de Haro Arbona
Ollie Inge
Ollie Inge
Jackson Hoffman
www.biorxiv.org
The spatial and temporal control of gene expression relies on transcription factors binding to and occupying their target sites. Transcription factor hubs - localized, high-concentration microenvironm...
www.cell.com
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
Big welcome to new postdoc Javier de Haro Arbona @fjavierdha.bsky.social, developmental biologist at heart and coming from Sarah Bray’s lab in Cambridge! Javier has been very interested in how signals are decoded and fate decisions encoded. We are lucky to have him join our lab!
Santos lab
Direct observation of Notch signalling induced transcription hubs mediating gene-expression responses https://www.biorxiv.org/content/10.1101/2025.07.04.663121v1
bioRxivpreprint
In our latest video, Silvia Santos and Borzo Gharibi of @santoslab.bsky.social explain how their team developed a new stem cell model of the mature amniotic sac, and why this will allow scientists to study the amniotic sac in more detail.
Watch now 👇
www.youtube.com/watch?v=8yjz...
