Online now: Pro-aging effects of chronic glucocorticoid signaling
Glucocorticoids regulate stress responses, metabolism, and inflammation, and chronic exposure promotes processes resembling accelerated aging through impaired autophagy, mitochondrial function, and cellular homeostasis. Kroemer and colleagues review how persistent GC signaling drives age-related diseases, examine the role of ACBP/DBI, and discuss strategies to mitigate GC-induced systemic aging across tissues.
