Check out our new work synthesizing (P^N^C)Gold(III) complexes, creating two new Au-C bonds in one pot! @chem.uzh.ch
Jaime Martín
Fantastic two weeks of science! Very happy to have participated at the Bienal @rseq-quimica.bsky.social and @eucomc2025.bsky.social sharing our advances in gold(III) chemistry, made at the @chem-uzh-ch.bsky.social. Thanks to the organisers for these great opportunities! @swisschemistry.bsky.social
My first post here comes with my latest work at the University of Zurich: Interrogating the anti-Insertion of Alkynes into Gold(III)! We explore the complex mechanism behind this apparently simple two-component reaction. Check it out in JACS Au pubs.acs.org/doi/10.1021/...
@uzhchemistry.bsky.social
Jaime Martín
Jaime Martín
'Synthesis of (P^N^C)Gold(III) Complexes via Tandem Oxidative Addition/C–H Auration' from ACS Organic & Inorganic Au is an open access #ACSEditorsChoice.
📖 Read the article: buff.ly/2UUBEnb
Congrats for this nice work now available in @jacsau.bsky.social by the group of Cristina Nevado
Interrogating the anti-Insertion of Alkynes into Gold(III) | JACS Au pubs.acs.org/doi/10.1021/...
ACS Publications
Alkyne hydrofunctionalizations are a powerful strategy to efficiently build up structural complexity. The selectivity of these reactions is typically governed by the interaction between the alkyne and a metal-hydride, which commonly proceeds via a well-understood syn-insertion mechanism. In contrast, anti-insertions are far less common, with proposed mechanisms often extrapolated from literature precedents rather than grounded in direct experimental evidence. While gold complexes rank among the most efficient catalysts for such transformations, the mechanistic understanding of the key alkyne insertion step remains incomplete. In this study, we demonstrate that stable gold(III)-hydrides, featuring a (P∧N∧C) ligand, undergo selective insertion of alkynes to yield the corresponding anti-Markovnikov Z-vinyl complexes. A combination of control experiments, kinetic studies, and computational analyses reveals a nonradical, bimolecular insertion process, in which water plays a pivotal role by accelerating the reaction and potentially stabilizing a highly reactive, T-shaped gold(I) intermediate. Notably, this is the first demonstration of the insertion of both activated and unactivated terminal and internal alkynes into a gold(III)-hydride complex.
'Synthesis of (P^N^C)Gold(III) Complexes via Tandem Oxidative Addition/C–H Auration' from ACS Organic & Inorganic Au is an open access #ACSEditorsChoice.
📖 Read the article: buff.ly/2UUBEnb
ACS Publications
Alkyne hydrofunctionalizations are a powerful strategy to efficiently build up structural complexity. The selectivity of these reactions is typically governed by the interaction between the alkyne and...
