Research Associate in the BioFrontiers Institute at CU Boulder. Postdoc: UPenn Bioengineering, PhD: UMN BME. Working at the interface between tissue engineering and developmental biology. He/him/his. Opinions are my own.
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Mapping nerves in a whole embryos.
We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry.
More here: www.biorxiv.org/content/10.6...
These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9
Earthset from Artemis II. I am overcome.
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
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New paper! Self-generated gradients in macrophage chemotaxis. Just published, by the esteemed Abhi Kiran and many collaborators.
A short skytorial follows.
journals.plos.org/plosbiology/...
🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...
Our latest manuscript on (Harry Potter and) the effect of elevated temperature on embryonic development in flies. Even a small increase in temperature causes developmental defects, indicating problems in the face of global warming! www.nature.com/articles/s41...
@lsprahl.bsky.social and Ronald Canlla in the lab just published a detailed study on remote-controlled epithelial budding morphogenesis. We can direct budding, tubule elongation, and perhaps branching in human kidney organoids via a light-activated RET receptor.
www.biorxiv.org/content/10.6...
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It's difficult to succinctly summarize a entire germ layer, but Aaron Zorn, Scott Rankin and I tried recently!
Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now.
shorturl.at/kHf9Y
For #FluorescenceFriday, an E10 embryo showing Pax2 localization. #DevelopmentalBiology
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Denis Wirtz
Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. This study shows that macrophages ...
Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...
Kale et al. show that nuclear divisions are defective at elevated temperature, leading to gastrulation defects and embryo lethality. Their work finds that F-actin – microtubule interactions during mit...
