The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
šļø Dozens more images with duplications or painting
šØļø Hundreds of blots that all share the same background (behold slideshow below)
Video
Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
Reese Richardson
www.biorxiv.org
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
Just returned from an incredible 3-day multi-lab retreat with the teams of Daniele Fachinetti, Nick @naltemose.bsky.social, and Dominika Gruszka in PĆŖra, Portugal. Sunshineš, great company š¤ and fantastic centromere and chromatin science š¬! Thanks to all the teams for this wonderful gathering!
Unbelievably, #DuvetKnowItsChristmas generates such good will on social media that over the years we've raised somewhere approaching a quarter of a million quid for homeless charities. If you can spare a bob or two, sling some to Centrepoint, and here's the link: www.gofundme.com/f/duvet-know...
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Unbelievably, it's the 15th year of this thing.
What is it?
Improbably, the nigā¦ Rhodri Marsden needs your support for Duvet Know It's Christmas, 2025
Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.
This year I'm hosting Christmas in my 1-bed flat. My brother has inherited last year's airbed setup and I've upgraded to an actual bed!
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
Shout-out to @fairbanc.bsky.social for letting me sleep in her house and hang out with her cat
