Working on fun label-free optical engineering, electrokinetics and biophysics projects at the lab of Sergii Pud. Previously in Leiden as PhD in the lab of Michel Orrit.
Jacco
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Thank you for such a clear definition!
Chromatix: a standardized framework for developing, sharing and reusing wave-optics simulations.
www.nature.com/articles/s41...
wikipedia turns 25 today! the last unenshittified major website! backbone of online info! triumph of humanity! powered by urge of unpaid randos to correct each other! somehow mostly reliable! "good thing wikipedia works in practice, because it sure doesn't work in theory" - old wiki adage
Jacco
New post: What is the impact of AI on productivity?
I review all of the studies and data that I can find and try to provide a synthesis.
A disagreement emerges: micro studies find positive benefits but these benefits are yet to show up in the macro data.
aleximas.substack.com/p/what-is-th... 🧵
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
Based on JAX, Chromatix provides a standardized framework for developing, sharing and reusing wave-optics simulations. The capabilities are demonstrated in a number of computational microscopy applica...
Plus, MDPI/Frontiers spend big money to convince governments they're not just legit, but leaders. Frontiers just sponsored WEF Davos, MDPI signed a deal with German national science agency.
🇩🇪+MDPI: www.timeshighereducation.com/news/germany...
Davos: sciencehouse.frontiersin.org/event/945d08...
2/3
Nature Methods
How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...
Welcome to the era of vibe science!
openai.com/index/introd...
Excited that our work on versatile and scalable micromirror inserts that enable high-contrast and high-resolution single-objective light sheet microscopy in conventional sample chambers is now published in Nano Letters!
doi.org/10.1021/acs....
@pubs.acs.org #soTILT3D #soLLS #microscopy #nanoscale
depths of wikipedia
Now online: October 2025 Issue.
- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...
www.nature.com/nnano/volume...
#PhysicsFactlet
Scattering VS Extinction
In #Optics, the concepts of scattering and extinction are closely related. So closely related that many people tend to confuse them.
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Video
Alex Imas
Mark A. Hanson
Landmark deal should raise questions about publisher’s practices on peer review, citations and special issues, say research sleuths
We present a tunable microfabrication pipeline for creating robust, reflective inserts that adapt conventional commercial imaging chambers for single-objective light sheet (LS) illumination. This system reduces the complexity associated with dual-objective LS setups and specialized LS chambers while retaining the native functionality and biocompatibility of the original chambers. The fabricated insert features a metalized, 3D nanoprinted micromirror with an angled reflective surface, enabling alignment of a thin LS for sectioning and imaging throughout mammalian cells. Using this pipeline, we demonstrate that single-objective LS illumination achieves an over 4X improvement in the signal-to-background ratio compared with conventional widefield epi-illumination in both fixed and live cell samples. Furthermore, we show substantial resolution enhancement for single-molecule localization microscopy compared to epi-illumination for improved imaging at the nanoscale. The versatile and scalable design offers an easily implemented approach to bring the benefits of single-objective LS microscopy to a wide array of biological studies.
