We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...
In #GENETICS, @jazlynmooney.bsky.social and the team present a unified theoretical framework for understanding how recombination shapes ancestry patterns after admixture.
🔗 buff.ly/7i4EFAc
Check out our new paper presenting pg-gpu, a GPU-accelerated population genetics python package:
www.biorxiv.org/content/10.6... 1/3
🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities.
www.biorxiv.org/content/10.6...
The 2026 Genomic History Inference Strategies Tournament is live! ghist.bio
Today was the kickoff tutorial at the Modeling and Theory in Population Biology workshop at @icerm.bsky.social . Looking forward to summer workshops at PEQG @genetics-gsa.bsky.social and at SMBE @official-smbe.bsky.social .
got my concluding slide on challenges with estimating ancestral recombination graphs ready for PEQG
postdoc alert 🚨! NIH-funded postdoc in my lab to work on Ancestral Recombination Graphs in space. Please spread the word widely in your networks, and please reach out if you're interested! (2-3yr position, start date flexible, pay/benefits good!).
details here: careers.umich.edu/job_detail/2...
#PEQG26 folks! I will be presenting my postdoc project with @jkpritch.bsky.social and @jeffspence.github.io about inferring population structure dynamics over time with tensor decomposition on ARG. The talk will be at the James Crow Talk session on Wednesday. Look forward to seeing everyone there!
Come see my poster tn! For 3 yrs, populations evolved at 43 sites worldwide. I built kMate, an alignment-free, pangenome k-mer method to track SNP & SV frequencies across space & time, opening the door to accurately and efficiently mapping climate-adaptive variants on evolution experiments! #PEQG26
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
www.biorxiv.org
Multiple positions available: Postdoc PhD students
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
