Some forms of heterologous competition for the patch are tolerated by cells, but an 'arginine anchor' causes profound problems. A truly fun collaboration between labs of Jim Kadonaga, JP Armache, EpiCypher & Jess Tyler [with cryo-EM of our Nucs and VHH straight from the freezer : no muss no fuss!]
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
