Very happy to share our new paper, where I am first author, developed at University of Chile.
Astrocytes were long overlooked as passive “support” cells, yet they play key roles in brain responses.
We explore how neuroinflammation alters astrocyte behaviour.
⚗️🧫🧪
link.springer.com/article/10.1...
Force coordination distinguishes epithelial and mesenchymal modes of collective #chemotaxis. New study from Jorge Diaz and Roberto Mayor @mayorlab.bsky.social @ucl.ac.uk: rupress.org/jcb/article/...
#Migration #motility #Development
Diaz and @mayorlab.bsky.social show that epithelial and mesenchymal cells navigate chemical cues via fundamentally different force-generating mechanisms, offering new insight into how diverse cell types achieve collective movement during development and disease. rupress.org/jcb/article/...
Two ways to move together: force coordination in collective #chemotaxis. Jessica Pacheco & Erica Hutchins @drericabiophd.bsky.social @ctbatucsf.bsky.social discuss study from @jorgediazfuentes.bsky.social & @mayorlab.bsky.social (rupress.org/jcb/article/...) in Spotlight rupress.org/jcb/article/...
Background Neuroinflammation induces astrogliosis, a process marked by astrocyte hypertrophy, increased migration, and altered protein expression. While these changes involve both up- and downregulati...
link.springer.com
Collective migration is not just about leaders at the front, but about coordination across the group.
Always exciting to see these dynamics visualized.
Many thanks to @jcb.org for featuring our work 🐸🔬🌹
Collectivity is not uniformity—it’s the coordination of forces under tension. In Xenopus neural crest epithelial clusters, movement emerges from within. From my postdoctoral research: nuclei (red), membranes (magenta), cytoskeleton (green). No internal tension, no collective motion. Tension holds 🐸🔬
So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everything🐸
Delighted to see our JCB work (rupress.org/jcb/article/...) beautifully summarized by Bits & Species
Mesenchymal and Epithelial-like Xenopus Neural Crest clusters use distinct force architectures to achieve comparable chemotactic performance
🐸🔬🧬🧫
IG feature: www.instagram.com/p/DUlACAJERdA/
Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology
Honored to see our work featured in a JCB Spotlight by Pacheco and @drericabiophd.bsky.social (@UCSF).
The piece discusses our study revealing distinct force-generating mechanisms in epithelial and mesenchymal collective migration
🔬🐸 Thank you for your careful review of our work!
hubs.la/Q042GFYY0
A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery:
doi.org/10.1083/jcb....
A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery:
doi.org/10.1083/jcb....
Journal of Cell Biology
Video
Video
Pacheco & @drericabiophd.bsky.social discuss new study from @jorgediazfuentes.bsky.social & @mayorlab.bsky.social (rupress.org/jcb/article/...) which reveals the distinct force-generating mechanisms used by epithelial and mesenchymal cells during collective cell migration rupress.org/jcb/article/...
