Hypoxic cancer cells are like race cars driving on flat tires. This study shows that a protein called kindlin-2 helps determine how prostate cancer cell membranes respond under low oxygen, influencing their mechanical resilience and behavior.
Lethal prostate cancer migrates through hypoxic regions and contractile muscle using mechanosensitive integrin receptors (specifically, β1 integrin heterodimers) to escape the organ. Kindlin-2 (K2)…
